Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression

Chauveau, Christine; Remy, Séverine; Royer, Pierre‐Joseph; Hill, Marcelo; Tanguy‐Royer, Séverine; Hubert, François‐Xavier; Tesson, Laurent; Brion, Régis; Bériou, Gaëlle; Grégoire, Marc; Josien, Régis; Cristina Cuturi, María; Anegón, Ignacio

doi:10.1182/blood-2005-02-0494

Public

Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression

Published in Blood • May 27, 2005

Authors:

Christine Chauveau

Séverine Remy

Pierre‐Joseph Royer

Abstract

Heme oxygenase-1 (HO-1) is an intracellular enzyme that degrades heme and inhibits immune responses and inflammation in vivo. In most cell types, HO-1 is inducible by inflammatory stimuli and oxidative stress. Here we demonstrate that human monocyte-derived immature dendritic cells (iDCs) and severa...

Subject

Proinflammatory cytokine

Heme oxygenase

Immune system

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