Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis

A. Vadas, Peter; Gold, Milton; Perelman, Boris; M. Liss, Gary; Lack, Gideon; Blyth, T; Estelle R. Simons, F.; J. Simons, Keith; Cass, Dan; M. Yeung, Jupiter

doi:10.1056/nejmoa070030

Public

Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis

Published in New England Journal of Medicine • Jan 2, 2008

Authors:

Peter A. Vadas

Milton Gold

Boris Perelman

Abstract

BACKGROUND: Platelet-activating factor (PAF) is an important mediator of anaphylaxis in animals, and interventions that block PAF prevent fatal anaphylaxis. The roles of PAF and PAF acetylhydrolase, the enzyme that inactivates PAF, in anaphylaxis in humans have not been reported. METHODS: We measure...

Subject

Anaphylaxis

Medicine

Platelet-activating factor

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