XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation

Margariti, Andriana; Li, Hongling; Chen, Ting; B. Martin, Daniel; Vizcay‐Barrena, Gema; Alam, Saydul; Karamariti, Eirini; Xiao, Qingzhong; Zampetaki, Anna; Zhang, Zhongyi; Wang, Wen; Jiang, Zhixin; Gao, Chan; Ma, Benyu; Chen, Ye‐Guang; Cockerill, Gillian; Hu, Yanhua; Xu, Qingbo; Zeng, Lingfang

doi:10.1074/jbc.m112.412783

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XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation

Published in Journal of Biological Chemistry • Nov 27, 2012

Authors:

Andriana Margariti

Hongling Li

Ting Chen

Abstract

Sustained activation of X-box-binding protein 1 (XBP1) results in endothelial cell (EC) apoptosis and atherosclerosis development. The present study provides evidence that XBP1 mRNA splicing triggered an autophagic response in ECs by inducing autophagic vesicle formation and markers of autophagy BEC...

Subject

XBP1

Autophagy

Cell biology

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