Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

Tsou, Wen-I; N. Nguyen, Khanh-Quynh; Calarese, D.A.; Garforth, S.; Antes, Anita; Sv, Smirnov; Almo, S.C.; B. Birge, Raymond; V. Kotenko, Sergei

doi:10.1074/jbc.m114.569020

Public

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

Published in Journal of Biological Chemistry • Jul 30, 2014

Authors:

Wen-I Tsou

Khanh-Quynh N. Nguyen

D.A. Calarese

Abstract

TYRO3, AXL, and MER receptors (TAMs) are three homologous type I receptor-tyrosine kinases that are activated by endogenous ligands, protein S (PROS1) and growth arrest-specific gene 6 (GAS6). These ligands can either activate TAMs as soluble factors, or, in turn, opsonize phosphatidylserine (PS) on...

Subject

GAS6

Receptor tyrosine kinase

MERTK

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