Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

M Gadaleta, Raffaella; J van Erpecum, Karel; Oldenburg, Bas; C L Willemsen, Ellen; Renooij, Willem; Murzilli, Stefania; W J Klomp, Leo; D Siersema, Peter; E I Schipper, Marguerite; Danese, Silvio; Penna, Giuseppe; Laverny, Gilles; Adorini, Luciano; Moschetta, Antonio; W C van Mil, Saskia

doi:10.1136/gut.2010.212159

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Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

Shared by NobleBlocks on Jan 17, 2011 • 12:00 AM UTC

Authors:

Raffaella M Gadaleta

Karel J van Erpecum

Bas Oldenburg

Abstract

Background & aims Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from dysregulation of the mucosal immune system and compromised intestinal epithelial barrier function. The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in inte...

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