Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

Maria Gadaleta, Raffaella; J. van Erpecum, Karel; Oldenburg, Bas; C.L. Willemsen, Ellen; Renooij, Willem; Murzilli, Stefania; W. J. Klomp, Leo; D. Siersema, Peter; Schipper, M.E.I.; Danese, Silvio; Penna, Giuseppe; LAVERNY, Gilles; Adorini, Luciano; Moschetta, Antonio; W. C. van Mil, Saskia

doi:10.1136/gut.2010.212159

Public

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

Published in Gut • Jan 17, 2011

Authors:

Raffaella Maria Gadaleta

Karel J. van Erpecum

Bas Oldenburg

Abstract

BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from dysregulation of the mucosal immune system and compromised intestinal epithelial barrier function. The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in int...

Subject

Proinflammatory cytokine

Inflammation

Inflammatory bowel disease

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