The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

Kozma, Robert; Ahmed, Sohail; Best, Anthony; Lim, Louis

doi:10.1128/mcb.15.4.1942

Public

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

Published in Molecular and Cellular Biology • Apr 1, 1995

Authors:

Robert Kozma

Sohail Ahmed

Anthony Best

Abstract

The Ras-related protein Cdc42 plays a role in yeast cell budding and polarity. Two related proteins, Rac1 and RhoA, promote formation in mammalian cells of membrane ruffles and stress fibers, respectively, which contain actin microfilaments. We now show that microinjection of the related human Cdc42...

Subject

Filopodia

Cell biology

Microinjection

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