Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor

C. Heinrich, Michael; Griffith, Diana; Druker, Brian; L. Wait, Cecily; A. Ott, Kristen; J. Zigler, Amy

doi:10.1182/blood.v96.3.925

Public

Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor

Published in Blood • Aug 1, 2000

Authors:

Michael C. Heinrich

Diana Griffith

Brian Druker

Abstract

STI 571 (formerly known as CGP 57148B) is a known inhibitor of the c-abl, bcr-abl, and platelet-derived growth-factor receptor (PDGFR) tyrosine kinases. This compound is being evaluated in clinical trials for the treatment of chronic myelogenous leukemia. We sought to extend the activity profile of ...

Subject

Tyrosine kinase

Platelet-derived growth factor receptor

Receptor tyrosine kinase

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