Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.

A, Omenetti; A, Porrello; Y, Jung; L, Yang; Y, Popov; SS, Choi; RP, Witek; G, Alpini; J, Venter; HM, Vandongen; WK, Syn; GS, Baroni; A, Benedetti; D, Schuppan; AM, Diehl

doi:10.1172/jci35875

Public

Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.

Shared by NobleBlocks on Oct 1, 2008 • 12:00 AM UTC

Authors:

Omenetti A

Porrello A

Jung Y

Abstract

Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after injury. Activation of the hedgehog (Hh) signaling pathway regulates EMT during development. This pat...

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