Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

Omenetti, Alessia; Porrello, Alessandro; Jung, Youngmi; Yang, Liu; Popov, Yury; S. Choi, Steve; P. Witek, Rafal; Alpini, Gianfranco; Venter, Juliet; M.A. VanDongen, Hendrika; Syn, Wing‐Kin; Svegliati‐Baroni, Gianluca; Benedetti, A.; Schuppan, Detlef; Mae Diehl, Anna

doi:10.1172/jci35875

Public

Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

Published in Journal of Clinical Investigation • Sep 18, 2008

Authors:

Alessia Omenetti

Alessandro Porrello

Youngmi Jung

Abstract

Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after injury. Activation of the hedgehog (Hh) signaling pathway regulates EMT during development. This pat...

Subject

Epithelial–mesenchymal transition

Cholangiocyte

Hedgehog signaling pathway

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