99mTc-cAbVCAM1-5 Imaging Is a Sensitive and Reproducible Tool for the Detection of Inflamed Atherosclerotic Lesions in Mice

Broisat, Alexis; Toczek, Jakub; Dumas, Laurent; Ahmadi, Mitra; Bacot, Sandrine; Perret, Pascale; Slimani, Lotfi; Barone‐Rochette, Gilles; Soubies, Audrey; Devoogdt, Nick; Lahoutte, Tony; Fagret, Daniel; Riou, Laurent; Ghezzi, Cathérine

doi:10.2967/jnumed.114.143792

Public

99mTc-cAbVCAM1-5 Imaging Is a Sensitive and Reproducible Tool for the Detection of Inflamed Atherosclerotic Lesions in Mice

Published in Journal of Nuclear Medicine • Aug 25, 2014

Authors:

Alexis Broisat

Jakub Toczek

Laurent Dumas

Abstract

UNLABELLED: (99m)Tc-cAbVCAM1-5, a single-domain antibody fragment directed against mouse or human vascular cell adhesion molecule 1 (VCAM-1), recently has been proposed as a new imaging agent for the detection of inflamed atherosclerotic lesions. Indeed, in a mouse model of atherosclerosis, (99m)Tc-...

Subject

Biodistribution

Atorvastatin

Nuclear medicine

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