Celecoxib for the Prevention of Colorectal Adenomatous Polyps

Arber, Nadir; Eagle, Craig; Špičák, Julius; Rácz, I; Dítě, Petr; Hajer, Jan; Zavoral, Miroslav; José Lechuga, María; Gerletti, Paola; Tang, Jie; B. Rosenstein, Rebecca; MacDonald, Katie; Bhadra, Pritha; Fowler, Robert; Wittes, Janet; G. Zauber, Ann; D. Solomon, Scott; Levin, Bernard

doi:10.1056/nejmoa061652

Public

Celecoxib for the Prevention of Colorectal Adenomatous Polyps

Published in New England Journal of Medicine • Aug 30, 2006

Authors:

Nadir Arber

Craig Eagle

Julius Špičák

Abstract

BACKGROUND: Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention. METHODS: The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, place...

Subject

Medicine

Celecoxib

Colonoscopy

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