DNA Hypermethylation of Promoter of Gene p53 and p16 in Arsenic-Exposed People with and without Malignancy

Chanda, Sarmishtha; B. Dasgupta, Uma; GuhaMazumder, Debendranath; Gupta, Mausumi; Chaudhuri, Utpal; Lahiri, Sarbari; Das, Subhankar; Ghosh, Nilima; Chatterjee, Debdutta

doi:10.1093/toxsci/kfj030

Public

DNA Hypermethylation of Promoter of Gene p53 and p16 in Arsenic-Exposed People with and without Malignancy

Published in Toxicological Sciences • Oct 26, 2005

Authors:

Sarmishtha Chanda

Uma B. Dasgupta

Debendranath GuhaMazumder

Abstract

Chronic arsenic exposure is known to produce arsenicosis and cancer. To ascertain whether perturbation of methylation plays a role in such carcinogenesis, the degree of methylation of p53 and p16 gene in DNA obtained from blood samples of people chronically exposed to arsenic and skin cancer subject...

Subject

DNA methylation

Methylation

Carcinogenesis

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