The Triterpenoid Betulin Protects against the Neuromuscular Effects of<i>Bothrops jararacussu</i>Snake Venom<i>In Vivo</i>

Cristina Ferraz, Miriéle; Luiz de Oliveira, Jhones; Reis de Oliveira, Joel; Carlos Cogo, José; Galdino dos Santos, Márcio; Madaleno Franco, Luiz; Puebla, Pilar; Onishi Ferraz, Helena; Gomes Ferraz, Humberto; Maria Teixeira da Rocha, Marisa; Hyslop, Stephen; San Feliciano, Arturo; Oshima‐Franco, Yoko

doi:10.1155/2015/939523

Public

The Triterpenoid Betulin Protects against the Neuromuscular Effects ofBothrops jararacussuSnake VenomIn Vivo

Published in Evidence-based Complementary and Alternative Medicine • Jan 1, 2015

Authors:

Miriéle Cristina Ferraz

Jhones Luiz de Oliveira

Joel Reis de Oliveira

Abstract

We confirmed the ability of the triterpenoid betulin to protect against neurotoxicity caused by Bothrops jararacussu snake venom in vitro in mouse isolated phrenic nerve-diaphragm (PND) preparations and examined its capability of in vivo protection using the rat external popliteal/sciatic nerve-tibi...

Subject

Venom

Bothrops

Pharmacology

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