High Cerebrospinal Fluid Tau and Low Amyloid β42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype

Galasko, Douglas; Chang, L.; Motter, Ruth; M. Clark, Christopher; Kaye, Jeffrey; S. Knopman, David; G. Thomas, Ronald; Kholodenko, Dora; Schenk, Dale; Lieberburg, Ivan; L. Miller, Bruce; Green, R.; Basherad, R.; Kertiles, L.; A. Boss, Michael; Seubert, Peter

doi:10.1001/archneur.55.7.937

Public

High Cerebrospinal Fluid Tau and Low Amyloid β42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype

Published in Archives of Neurology • Jul 1, 1998

Authors:

Douglas Galasko

L. Chang

Ruth Motter

Abstract

OBJECTIVE: To evaluate cerebrospinal fluid (CSF) levels of amyloid beta protein ending at amino acid 42 (Abeta42) and tau as markers for Alzheimer disease (AD) and to determine whether clinical variables influence these levels. DESIGN: Cohort study. SETTING: Six academic research centers with expert...

Subject

Dementia

Internal medicine

Apolipoprotein E

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