A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

D. Coviello, Andrea; Haring, Robin; Wellons, Melissa; Vaidya, Dhananjay; Lehtimäki, Terho; Keildson, Sarah; L. Lunetta, Kathryn; He, Chunyan; Fornage, Myriam; Lagou, Vasiliki; Mangino, Massimo; Charlotte Onland‐Moret, N.; H. Chen, Brian; Eriksson, Joel; García, Melissa; Mei Liu, Yong; Koster, Annemarie; Lohman, Kurt; Lyytikäinen, Leo‐Pekka; Petersen, Ann-Kristin; Prescott, Jennifer; Stolk, Lisette; Vandenput, Liesbeth; R. Wood, Andrew; Zhuang, Wei; Ruokonen, Aimo; Hartikainen, Anna‐Liisa; Pouta, Anneli; Bandinelli, Stefania; Biffar, Reiner; Brabant, Georg; G. Cox, David; Chen, Yuhui; R. Cummings, Steven; Ferrucci, Luigi; J. Gunter, Marc; E. Hankinson, Susan; Martikainen, Hannu; Hofman, Albert; Homuth, Georg; Illig, Thomas; Jansson, John‐Olov; D. Johnson, Andrew; Karasik, David; K. Karlsson, Magnus; Kettunen, Johannes; P. Kiel, Douglas; Kraft, Peter; Liu, Jingmin; Ljunggren, Östen; Lorentzon, Mattias; Maggio, Marcello; Ricardo Paulista Markus, Marcello; Mellström, Dan; Miljkovic, Iva; B. Mirel, Daniel; C. Nelson, Sarah; Morin‐Papunen, Laure; H. Peeters, Petra; Prokopenko, Inga; J. Raffel, Leslie; Reincke, Martín; P. Reiner, Alex; M. Rexrode, Kathryn; Rivadeneira, Fernando; M. Schwartz, Stephen; S. Siscovick, David; Soranzo, Nicole; Stöckl, Doris; S. Tworoger, Shelley; G. Uitterlinden, André; H. van Gils, Carla; S. Vasan, Ramachandran; Wichmann, Hans; Zhai, Guangju; Bhasin, Shalender; Bidlingmaier, Martin; J. Chanock, Stephen; De Vivo, Immaculata; B. Harris, Tamara; J. Hunter, David; Kähönen, Mika; Liu, Simin; Ouyang, Pamela; D. Spector, Tim; T. van der Schouw, Yvonne; Viikari, Jorma; Wallaschofski, Henri; I. McCarthy, Mark; M. Frayling, Timothy; Murray, Anna; Franks, Steve; Järvelin, Marjo‐Riitta; H. de Jong, Frank; Raitakari, Olli; Teumer, Alexander; Ohlsson, Claes; M. Murabito, Joanne; R. B. Perry, John

doi:10.1371/journal.pgen.1002805

Public

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Published in PLoS Genetics • Jul 19, 2012

Authors:

Andrea D. Coviello

Robin Haring

Melissa Wellons

Abstract

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breas...

Subject

Biology

Sex hormone-binding globulin

Genome-wide association study

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