ALDEN, an Algorithm for Assessment of Drug Causality in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Comparison With Case–Control Analysis

Sassolas, B.; Haddad, Cynthia; Mockenhaupt, Maja; Dunant, Ariane; Liss, Y; Bork, Konrad; Haustein, U.-F.; Vieluf, Dieter; Roujeau, J.C.; Le Louët, Hervé

doi:10.1038/clpt.2009.252

Public

ALDEN, an Algorithm for Assessment of Drug Causality in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Comparison With Case–Control Analysis

Published in Clinical Pharmacology & Therapeutics • Apr 7, 2010

Authors:

B. Sassolas

Cynthia Haddad

Maja Mockenhaupt

Abstract

Epidermal necrolysis (EN)--either Stevens-Johnson syndrome (SJS) or toxic EN (TEN)--is a severe drug reaction. We constructed and evaluated a specific algorithm, algorithm of drug causality for EN (ALDEN), in order to improve the individual assessment of drug causality in EN. ALDEN causality scores ...

Subject

Toxic epidermal necrolysis

Causality (physics)

Pharmacovigilance

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