Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

Lande, Roberto; Ganguly, Dipyaman; Facchinetti, Valeria; Frasca, Loredana; Conrad, Curdin; Gregorio, Josh; Meller, Stephan; Chamilos, Georgios; Sebasigari, Rosalie; Riccieri, Valeria; L. Bassett, Roland; Amuro, Hideki; Fukuhara, Shirou; Ito, Tomoki�; Liu, Yong-Jun; Gilliet, Michel

doi:10.1126/scitranslmed.3001180

Public

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

Published in Science Translational Medicine • Mar 9, 2011

Authors:

Roberto Lande

Dipyaman Ganguly

Valeria Facchinetti

Abstract

Systemic lupus erythematosus (SLE) is a severe and incurable autoimmune disease characterized by chronic activation of plasmacytoid dendritic cells (pDCs) and production of autoantibodies against nuclear self-antigens by hyperreactive B cells. Neutrophils are also implicated in disease pathogenesis;...

Subject

Neutrophil extracellular traps

Autoantibody

Immunology

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