<i>IFNAR1</i> Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in <i>Plasmodium berghei</i>–Infected Mice

Ann Ball, Elizabeth; Rosário Sambo, Maria; Martins, Madalena; Jesus Trovoada, Maria; Benchimol, Carla; Costa, João; Antunes Gonçalves, Lígia; Coutinho, António; Penha‐Gonçalves, Carlos

doi:10.4049/jimmunol.1300114

Public

IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei–Infected Mice

Published in The Journal of Immunology • Apr 13, 2013

Authors:

Elizabeth Ann Ball

Maria Rosário Sambo

Madalena Martins

Abstract

Development of cerebral malaria (CM), a severe and fatal form of clinical Plasmodium falciparum infection, results from a damaging cascade of vascular, inflammatory, and immunological host responses that leads to brain injury. Progression to CM can be modified by host genetic factors. Our case-contr...

Subject

Plasmodium berghei

Biology

CD8

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