Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y1 receptor–null mice

Léon, Catherine; Hechler, Béatrice; Freund, Monique; Eckly, Anita; Vial, Catherine; Ohlmann, Philippe; Dierich, Andrée; LeMeur, Marianne; Cazenave, Jean‐Pierre; Gachet, Christian

doi:10.1172/jci8399

Public

Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y1 receptor–null mice

Published in Journal of Clinical Investigation • Dec 15, 1999

Authors:

Catherine Léon

Béatrice Hechler

Monique Freund

Abstract

ADP is a key agonist in hemostasis and thrombosis. ADP-induced platelet activation involves the purinergic P2Y(1) receptor, which is responsible for shape change through intracellular calcium mobilization. This process also depends on an unidentified P2 receptor (P2cyc) that leads to adenylyl cyclas...

Subject

P2Y receptor

Purinergic receptor

Adenylyl cyclase

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