Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

G. Healy, Daniel; Falchi, Mario; S. O’Sullivan, Sean; Bonifati, Vincenzo; Durr, Alexandra; Bressman, Susan; Brice, Alexis; Aasly, Jan; P. Zabetian, Cyrus; Goldwurm, Stefano; J. Ferreira, Joaquim; Tolosa, Eduardo; M. Kay, Denise; Klein, Christine; R. Williams, David; Marras, Connie; E. Lang, Anthony; K. Wszołek, Zbigniew; Berciano, José; H.V. Schapira, Anthony; Lynch, Timothy; P. Bhatia, Kailash; Gasser, Thomas; J. Lees, Andrew; Wood, Nicholas

doi:10.1016/s1474-4422(08)70117-0

Public

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

Published in The Lancet Neurology • Jun 8, 2008

Authors:

Daniel G. Healy

Mario Falchi

Sean S. O’Sullivan

Abstract

BACKGROUND: Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to answer three key clinical questions: can LRRK2-associated PD be distinguished from idiopathic PD; which mutations in LRRK...

Subject

LRRK2

Penetrance

Disease

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