Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

Meijer, Laurent; Borgne, Annie; Mulner, Odile; Chong, J.; Julian Blow, J.; Inagaki, Naoyuki; Inagaki, Masaki; Delcros, Jean‐Guy; Moulinoux, Jacques‐Philippe

doi:10.1111/j.1432-1033.1997.t01-2-00527.x

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Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

Published in European Journal of Biochemistry • Jan 1, 1997

Authors:

Laurent Meijer

Annie Borgne

Odile Mulner

Abstract

Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These kinases and their regulators are frequently deregulated in human tumours. Enzymatic screening has recently led to the discovery of specific inhibitors of cyclin-dependent kinase...

Subject

Cyclin-dependent kinase

Cyclin-dependent kinase 2

Biology

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