Association of a Functional Deficit of the BK Ca Channel, a Synaptic Regulator of Neuronal Excitability, With Autism and Mental Retardation

Laumonnier, Frédéric; Roger, Sébastien; Guérin, Pascaline; Molinari, Florence; Mrad, Ridha; Cahard, Dominique; Belhadj, A.; Halayem, M.B.; M. Persico, Antonio; Elia, Maurizio; Romano, Valentino; Holbert, Sébastien; Andrés, Christian; Chaâbouni, Habiba; Colleaux, Laurence; Constant, Jacques; Le Guennec, Jean-Yves; Briault, Sylvain

doi:10.1176/ajp.2006.163.9.1622

Public

Association of a Functional Deficit of the BK Ca Channel, a Synaptic Regulator of Neuronal Excitability, With Autism and Mental Retardation

Published in American Journal of Psychiatry • Sep 1, 2006

Authors:

Frédéric Laumonnier

Sébastien Roger

Pascaline Guérin

Abstract

OBJECTIVE: Autism is a complex, largely genetic psychiatric disorder. In the majority of cases, the cause of autism is not known, but there is strong evidence for a genetic etiology. To identify candidate genes, the physical mapping of balanced chromosomal aberrations is a powerful strategy, since s...

Subject

Autism

Haploinsufficiency

Neuroscience

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