Systematic identification of trans eQTLs as putative drivers of known disease associations

Westra, Harm-Jan; J. Peters, Marjolein; Esko, Tõnu; Yaghootkar, Hanieh; Schurmann, Claudia; Kettunen, Johannes; Christiansen, Mark; P. Fairfax, Benjamin; Schramm, Katharina; E. Powell, Joseph; Zhernakova, Alexandra; V. Zhernakova, Daria; H. Veldink, Jan; H. van den Berg, Leonard; Karjalainen, Juha; Withoff, Sebo; G. Uitterlinden, André; Hofman, Albert; Rivadeneira, Fernando; A.C. ’t Hoen, Peter; Reinmaa, Eva; Fischer, Krista; Nelis, Mari; Milani, Lili; Melzer, David; Ferrucci, Luigi; Singleton, Andrew; Hernández, Dena; A. Nalls, Michael; Homuth, Georg; Nauck, Matthias; Radke, Dörte; Völker, Uwe; Perola, Markus; Salomaa, Veikko; A. Brody, Jennifer; M. Suchy‐Dicey, Astrid; A. Gharib, Sina; A. Enquobahrie, Daniel; Lumley, Thomas; W. Montgomery, Grant; Makino, Seiko; Prokisch, Holger; Herder, Christian; Roden, Michael; Grallert, Harald; Meitinger, Thomas; Strauch, Konstantin; Li, Yang; C. Jansen, Ritsert; M. Visscher, Peter; C. Knight, Julian; M. Psaty, Bruce; Ripatti, Samuli; Teumer, Alexander; M. Frayling, Timothy; Metspalu, Andres; B. J. van Meurs, Joyce; Franke, Lude

doi:10.1038/ng.2756

Public

Systematic identification of trans eQTLs as putative drivers of known disease associations

Published in Nature Genetics • Sep 8, 2013

Authors:

Harm-Jan Westra

Marjolein J. Peters

Tõnu Esko

Abstract

Identifying the downstream effects of disease-associated SNPs is challenging. To help overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in non-transformed peripheral blood samples from 5,311 individuals with replication in 2,775 individuals. We identified a...

Subject

Expression quantitative trait loci

Biology

Genetics

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