A Genetic Risk Score Is Associated With Incident Cardiovascular Disease and Coronary Artery Calcium

Thanassoulis, George; M. Peloso, Gina; J. Pencina, Michael; Hoffmann, Udo; S. Fox, Caroline; Adrienne Cupples, L.; Levy, Daniel; B. D’Agostino, Ralph; Hwang, Shih‐Jen; J. O’Donnell, Christopher

doi:10.1161/circgenetics.111.961342

Public

A Genetic Risk Score Is Associated With Incident Cardiovascular Disease and Coronary Artery Calcium

Published in Circulation Cardiovascular Genetics • Jan 11, 2012

Authors:

George Thanassoulis

Gina M. Peloso

Michael J. Pencina

Abstract

BACKGROUND: Limited data exist regarding the use of a genetic risk score (GRS) for predicting risk of incident cardiovascular disease (CVD) in US-based samples. METHODS AND RESULTS: By using findings from recent genome-wide association studies, we constructed GRSs composed of 13 genetic variants ass...

Subject

Single-nucleotide polymorphism

Hazard ratio

Medicine

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