Frequent deletions and down-regulation of micro- RNA genes
                    <i>miR15</i>
                    and
                    <i>miR16</i>
                    at 13q14 in chronic lymphocytic leukemia

Adrian Calin, George; Dan Dumitru, Calin; Shimizu, Masayoshi; Bichi, Roberta; Zupo, Simona; Noch, Evan; Aldler, Hansjuerg; Rattan, Sashi; Keating, Michael; Rai, Kanti; Rassenti, Laura; Kipps, Thomas; Negrini, Massimo; Bullrich, Florencia; M. Croce, Carlo

doi:10.1073/pnas.242606799

Public

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Shared by NobleBlocks on Nov 14, 2002 • 12:00 AM UTC

Authors:

George Adrian Calin

Calin Dan Dumitru

Masayoshi Shimizu

Abstract

Micro-RNAs ( miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors (≈70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes ta...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!