A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

T. Le, Dung; G. Brockstedt, Dirk; Nir‐Paz, Ran; Hampl, Johannes; Mathur, Shruti; Nemunaitis, John; H. Sterman, Daniel; Hassan, Raffit; R. Lutz, Eric; Moyer, Bentley; Giedlin, Martin; Louis, Jana-Lynn; A. Sugar, Elizabeth; Pons, Alice; L. Cox, Andrea; Levine, Jordana; Murphy, Aimee; B. Illei, Peter; W. Dubensky, Thomas; E. Eiden, Joseph; M. Jaffee, Elizabeth; A. Laheru, Daniel

doi:10.1158/1078-0432.ccr-11-2121

Public

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

Published in Clinical Cancer Research • Dec 6, 2011

Authors:

Dung T. Le

Dirk G. Brockstedt

Ran Nir‐Paz

Abstract

PURPOSE: Listeria monocytogenes (Lm)-based vaccines stimulate both innate and adaptive immunity. ANZ-100 is a live-attenuated Lm strain (Lm ΔactA/ΔinlB). Uptake by phagocytes in the liver results in local inflammatory responses and activation and recruitment of natural killer (NK) and T cells, in as...

Subject

Mesothelin

Medicine

Immune system

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