The PHD/LAP-Domain Protein M153R of Myxomavirus Is a Ubiquitin Ligase That Induces the Rapid Internalization and Lysosomal Destruction of CD4

Mansouri, Mandana; Bartee, Eric; Gouveia, Kristine; T. Hovey Nerenberg, Bianca; W. Barrett, John; Thomas, Laurel; Thomas, Gary; McFadden, Grant; Früh, Klaus

doi:10.1128/jvi.77.2.1427-1440.2003

Public

The PHD/LAP-Domain Protein M153R of Myxomavirus Is a Ubiquitin Ligase That Induces the Rapid Internalization and Lysosomal Destruction of CD4

Published in Journal of Virology • Dec 26, 2002

Authors:

Mandana Mansouri

Eric Bartee

Kristine Gouveia

Abstract

The genomes of several poxviruses contain open reading frames with homology to the K3 and K5 genes of Kaposi's sarcoma-associated herpesvirus (KSHV) and the K3 gene of murine gammaherpesvirus 68, which target major histocompatibility complex class I (MHC-I) as well as costimulatory molecules for pro...

Subject

Biology

Ubiquitin ligase

Ubiquitin

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