Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Beecham, Ashley; Hadjixenofontos, Athena; Konidari, Ioanna; P. Manrique, Clara; A Pericak‐Vance, Margaret; L. McCauley, Jacob; A. Patsopoulos, Nikolaos; Y. Frohlich, Irene; Lee, Michelle; L. De Jager, Philip; K. Xifara, Dionysia; Spencer, Chris; Band, Gavin; Bellenguez, Céline; Dilthey, Alexander; Donnelly, Peter; Freeman, Colin; Moutsianas, Loukas; Pirinen, Matti; Strange, Amy; McVean, Gil; F. Davis, Mary; Schnetz‐Boutaud, Nathalie; L. Haines, Jonathan; Kemppinen, Anu; Ban, Maria; Baker, Amie; Fiddes, Barnaby; Compston, Alastair; Sawcer, Stephen; Cotsapas, Chris; McCabe, Cristin; A. Hafler, David; Shah, Tejas; A. Anderson, Carl; Andrews, Robert; C. Barrett, Jeffrey; Blackburn, Hannah; Deloukas, Panos; Edkins, Sarah; Hunt, Sarah; Langford, Cordelia; J. Booth, David; Vucic, Steve; J. Stewart, Graeme; Goris, An; Cosemans, Leentje; Dubois, Bénédicte; Oturai, Annette; Bach Søndergaard, Helle; Sellebjerg, Finn; Soelberg Sørensen, Per; Saarela, Janna; Leppä, Virpi; Fontaine, Bertrand; Cournu‐Rebeix, Isabelle; Damotte, Vincent; Hemmer, Bernhard; Berthele, Achim; Biberacher, Viola; Buck, Dorothea; Grummel, Verena; Hoshi, Muni; Jochim, Angela; Korn, Thomas; Kronsbein, Helena; Selter, Rebecca; Winkelmann, JC; Martin, Claes; Zipp, Frauke; Graetz, Christiane; M. Lill, Christina; Luessi, Felix; Siffrin, Volker; Zindler, Eva; D’Alfonso, Sandra; Barizzone, Nadia; L, Bergamaschi; Corrado, Lucia; Martinelli-Boneschi, Filippo; Brambilla, Paola; Comı, Gıancarlo; Esposito, Federica; Guaschino, Clara; Liberatore, Giuseppe; Sorosina, Melissa; Martinelli, Vittorio; Rodegher, Mariaemma; Taylor, Bruce; F. Harbo, Hanne; Gulowsen Celius, Elisabeth; L Mero, I; A Lie, B; Kockum, Ingrid; Hillert, J; Olsson, Tomas; Lima Bomfim, Izaura; Brundin, Lou; Jagodic, Maja; Lindén, Magdalena; Link, Jenny; Piehl, F; Sundqvist, Emilie; Westerlind, Helga; R. Oksenberg, Jorge; E. Baranzini, Sergio; J Caillier, Stacy; Cree, Bruce; Gourraud, Pierre‐Antoine; L. Hauser, Stephen; Hintzen, Rogier; Mescheriakova, Julia; F. Barcellos, Lisa; Quach, Hong; Schaefer, Catherine; Shen, Ling; Agliardi, Cristina; Alfredsson, Lars; Alizadeh, Mehdi; Bernardinelli, Luisa; M. C. Binder, Thomas; Broadley, Simon; Brochet, Bruno; Butzkueven, Helmut; Camu, William; Carpentier, Wassila; Cavalla, Paola; Coman, Irène; Cusi, Daniele; Defer, Gilles; Delgado, Silvia; Di Sapio, Alessia; Duddy, Martin; Elovaara, Irina; Evangelou, Nikos; Field, Judith; S. Wiley, James; Franke, André; Galimberti, Daniela; Gieger, Christian; Graham, Andrew; Håkonarson, Håkon; Halfpenny, Christopher; Hall, Gillian; Hall, Per; Hamsten, Anders; Harley, James; Harrower, Timothy; Hawkins, Clive; Hellenthal, Garrett; Hillier, Charles; Hobart, Jeremy; Zajicek, John; Jelčić, I; Martinꝉ, Roland; Sospedra, Mireia; Kendall, B.; G. Kermode, Allan; J. Kilpatrick, Trevor; Koivisto, Keijo; Larsson, Malin; Lathrop, Mark; Lebrun-Frenay, Christine; Js, Lechner-Scott; Leone, Maurizio; Lycke, Jan; Macciardi, Fabio; Männistö, Satu; Mason, Deborah; Mazibrada, Gordon; Myhr, Kjell-Morten; Nagels, Guy; Nicholas, RS; Nilsson, PG; Price, Siân; Reunanen, M; Robberecht, W; Thijs, Vincent; NP, Robertson; Rog, David; Salvetti, Marco; Shaunak, Sandip; Shields, S; Slee, Mark; Spurkland, Anne; Thorpe, John; Ticca, Anna; Tienari, P; van Duijn, Cornelia; Visser, Elizabeth; Wilkins, Alastair; T Wilson, J; J. Ivinson, Adrian

doi:10.1038/ng.2770

Public

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Published in Nature Genetics • Sep 29, 2013

Authors:

Ashley Beecham

Athena Hadjixenofontos

Ioanna Konidari

Abstract

The International Multiple Sclerosis Genetics Consortium reports the discovery of 48 new susceptibility variants for multiple sclerosis through targeted follow-up of immune-related loci. They also report fine mapping of association signals at established susceptibility loci and provide insights into...

Subject

Multiple sclerosis

Genome-wide association study

Biology

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