The Antiapoptotic Gene <i>mcl-1</i> Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

Wang, Ju‐Ming; Chao, Jyh-Rong; Chen, Wannhsin; Kuo, Min‐Liang; J. Yen, J.; Yang‐Yen, Hsin‐Fang

doi:10.1128/mcb.19.9.6195

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The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

Published in Molecular and Cellular Biology • Sep 1, 1999

Authors:

Ju‐Ming Wang

Jyh-Rong Chao

Wannhsin Chen

Abstract

mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) signaling pathways and plays an important role in the viability response of these cytokines. In this study, we demonstrated that cytokine stimulation of mcl-1 mRNA and...

Subject

Biology

CREB

Protein kinase B

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