A Single Amino-Acid Change in a Highly Conserved Motif of gp41 Elicits HIV-1 Neutralization and Protects Against CD4 Depletion

Petitdemange, Caroline; Achour, Abla; Dispinseri, Stefania; Malet, Isabelle; Sennepin, Alexis; Ho Tsong Fang, Raphaël; Crouzet, Joël; Marcelin, Anne‐Geneviève; Cálvez, Vincent; Scarlatti, Gabriella; Debré, Patrice; Vieillard, Vincent

doi:10.1093/cid/cit335

Public

A Single Amino-Acid Change in a Highly Conserved Motif of gp41 Elicits HIV-1 Neutralization and Protects Against CD4 Depletion

Published in Clinical Infectious Diseases • May 21, 2013

Authors:

Caroline Petitdemange

Abla Achour

Stefania Dispinseri

Abstract

BACKGROUND: The induction of neutralizing antibodies against conserved regions of the human immunodeficiency virus type 1 (HIV-1) envelope protein is a major goal of vaccine strategies. We previously identified 3S, a critical conserved motif of gp41 that induces the NKp44L ligand of an activating NK...

Subject

Neutralization

Human immunodeficiency virus (HIV)

Gp41

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