Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

J. Kwiatkowski, Thomas; A. Bosco, Daryl; Leclerc, Aurélie; Tamrazian, Eric; Vanderburg, Charles; Russ, C; Davis, Adam; M. Gilchrist, James; J. Kasarskis, Edward; L. Munsat, T.; N. Valdmanis, Paul; A. Rouleau, Guy; A. Hosler, Betsy; Cortelli, Pietro; J. de Jong, Pieter; Yoshinaga, Yuko; L. Haines, J.; A. Pericak‐Vance, Margaret; Yan, J; Ticozzi, Nicola; Siddique, Teepu; McKenna‐Yasek, D.; C. Sapp, Peter; Robert Horvitz, H.; E. Landers, John; H. Brown, Robert

doi:10.1126/science.1166066

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Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

Published in Science • Feb 26, 2009

Authors:

Thomas J. Kwiatkowski

Daryl A. Bosco

Aurélie Leclerc

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder. Ten percent of cases are inherited; most involve unidentified genes. We report here 13 mutations in the fused in sarcoma/translated in liposarcoma (FUS/TLS) gene on chromosome 16 that were specific for familial ALS. T...

Subject

Amyotrophic lateral sclerosis

Biology

Gene

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