Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Manske, Magnus; Miotto, Olivo; Campino, Susana; Auburn, Sarah; Almagro‐Garcia, Jacob; Maslen, G.; C. O’Brien, Jack; Djimdé, Abdoulaye; K. Doumbo, Ogobara; Zongo, Issaka; Ouédraogo, Jean‐Bosco; Michon, P; Müeller, Ivo; Siba, Peter; Nzila, Alexis; Borrmann, Steffen; M. Kiara, Steven; Marsh, Kevin; Jiang, Hongying; Su, Xin‐zhuan; Amaratunga, Chanaki; M. Fairhurst, Rick; Socheat, Duong; Nosten, François; Imwong, Mallika; J. White, Nicholas; Sanders, Mandy; Anastasi, Elisa; Alcock, Dan; Drury, Eleanor; O. Oyola, Samuel; A. Quail, Michael; J. Turner, Daniel; Ruano-Rubio, Valentín; Jyothi, Dushyanth; Amenga–Etego, Lucas; Hubbart, Christina; E. Jeffreys, Anna; Rowlands, Kate; J. Sutherland, Colin; Roper, Cally; Mangano, Valentina; Modiano, David; C. Tan, John; T. Ferdig, Michael; Amambua‐Ngwa, Alfred; J. Conway, David; Takala‐Harrison, Shannon; V. Plowe, Christopher; C. Rayner, Julian; A. Rockett, Kirk; G. Clark, Taane; Newbold, Chris; Berriman, Matthew; MacInnis, Bronwyn; Kwiatkowski, Dominic

doi:10.1038/nature11174

Public

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Published in Nature • Jun 12, 2012

Authors:

Magnus Manske

Olivo Miotto

Susana Campino

Abstract

Next-generation sequencing is used here to analyse Plasmodium falciparum genome variation directly from clinical blood samples, as well as cultured isolates, from Africa, Asia and Oceania. Resistance to the major antimalarial drug artemisinin is emerging in the Plasmodium falciparum parasite across ...

Subject

Plasmodium falciparum

Biology

Malaria

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