IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25

Létourneau, Sven; M. M. van Leeuwen, Ester; Krieg, Carsten; Martin, Chris; Pantaleo, Giuseppe; Sprent, Jonathan; D. Surh, Charles; Boyman, Onur

doi:10.1073/pnas.0909384107

Public

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25

Published in Proceedings of the National Academy of Sciences • Jan 19, 2010

Authors:

Sven Létourneau

Ester M. M. van Leeuwen

Carsten Krieg

Abstract

IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown ...

Subject

IL-2 receptor

Homeostasis

Antibody

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!