Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia

Ohno, Ryuzo; Tomonaga, Masao; Kobayashi, Tohru; Kanamaru, Akihisa; Shirakawa, Shigeru; Masaoka, T; Omine, Mitsuhiro; Oh, Hakumei; Nomura, Takeo; Sakai, Yasunobu; Hirano, Masami; Yokomaku, S; Nakayama, Shiro; Yoshida, Yutaka; Miura, Akira; Morishima, Yasuo; Dohy, Hiroo; Niho, Yoshiyuki; Hamajima, Nobuyuki; Takaku, Fumimaro

doi:10.1056/nejm199009273231304

Public

Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia

Published in New England Journal of Medicine • Sep 27, 1990

Authors:

Ryuzo Ohno

Masao Tomonaga

Tohru Kobayashi

Abstract

Background. Although colony-stimulating factors have been shown to accelerate recovery from severe neutropenia after intensive chemotherapy or bone marrow transplantation, their use in acute leukemia has been controversial because in vitro they stimulate leukemic colonies as well as normal granulocy...

Subject

Medicine

Neutropenia

Granulocyte colony-stimulating factor

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