DNAzyme Targeting c- <i>jun</i> Suppresses Skin Cancer Growth

Cai, Hong; S. Santiago, Fernando; Prado-Lourenço, Leonel; Wang, Bo; Patrikakis, Margaret; P. Davenport, Miles; J. Maghzal, Ghassan; Stocker, Roland; R. Parish, Christopher; H. Chong, Beng; J. Lieschke, Graham; Wong, Tak‐Wah; N. Chesterman, Colin; J. Francis, Douglas; J. Moloney, Fergal; St.C. Barnetson, Ross; M. Halliday, Gary; M. Khachigian, Levon

doi:10.1126/scitranslmed.3003960

Public

DNAzyme Targeting c- jun Suppresses Skin Cancer Growth

Published in Science Translational Medicine • Jun 20, 2012

Authors:

Hong Cai

Fernando S. Santiago

Leonel Prado-Lourenço

Abstract

Worldwide, one in three cancers is skin-related, with increasing incidence in many populations. Here, we demonstrate the capacity of a DNAzyme-targeting c-jun mRNA, Dz13, to inhibit growth of two common skin cancer types-basal cell and squamous cell carcinomas-in a therapeutic setting with establish...

Subject

Deoxyribozyme

c-jun

Cancer research

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