Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women

Houde, Andrée-Anne; Légaré, Cécilia; Biron, Simon; Lescelleur, Odette; Biertho, Laurent; Marceau, Simon; Tchernof, André; Vohl, Marie‐Claude; Hivert, Marie‐France; Bouchard, Luigi

doi:10.1186/s12881-015-0174-1

Public

Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women

Published in BMC Medical Genetics • Apr 30, 2015

Authors:

Andrée-Anne Houde

Cécilia Légaré

Simon Biron

Abstract

BACKGROUND: Leptin (LEP) and adiponectin (ADIPOQ) genes encode adipokines that are mainly secreted by adipose tissues, involved in energy balance and suspected to play a role in the pathways linking adiposity to impaired glucose and insulin homeostasis. We have thus hypothesized that LEP and ADIPOQ ...

Subject

DNA methylation

Adiponectin

Endocrinology

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