Adjunctive perampanel for refractory partial-onset seizures

A. French, Jacqueline; L. Krauss, Gregory; Biton, Victor; Squillacote, David; Yang, Haichen; Laurenza, Antonio; Kumar, Dinesh; A. Rogawski, Michael; Campanille, Verónica; Floridia, Jorge; Ilari, Rita; Consalvo, D.; Thomson, Alfredo; Sfaello, Ignacio; Pociecha, Juan; Nieto, Flavia; José Firstenfeld, Alfredo; Raúl Zuin, Daniel; C. Mesri, Jacobo; Silva, Walter; Nofal, Pedro; Cristalli, Diana; Clément, Jean‐François; M. Hwang, Paul; S. McLachlan, Richard; Pillay, Neelan; Lasso, Jorge; Peralta, B; Leiva Hernandez, Marcelo; Tenhamm, E; Barroso, Noe; Contreras Milian, Albino; Reyes Morales, Sarug; Rodríguez‐Leyva, Ildefonso; Jain, Sanjay; A. Wilfong, Angus; Kalra, Arun; Renfroe, Ben; Moore, David; Robert Flamini, J.; A. Klapper, Jack; P. Szaflarski, Jerzy; Teasley, Jean; J. Halford, Jonathan; Alexandre Ferreira, José; C. Goodpasture, Hewitt; R. Sperling, Michael; Klein, Pavel; Ayala, Ricardo; Brower, Richard; Leroy, Robert; L. Davis, Ronald; D. Elterman, Roy; Enlow, Thomas; Sosa, Verónica; Puri, Vinay; Philip Miller, J.; F. Shneker, Bassel; Edmundo D. Bautista, Ramon; Chung, Steve; Lesch, David; F. Steiner, David; Webb, Randall; Armstrong, Robert; Biton, Victor; L. Krauss, Gregory; G. Mitchell, Wendy; Edward Hogan, R.; C. Knowlton, Robert; W. Wheless, James; Aung-Din, R.; Ali, Imran; W. Brown, Lawrence; Gruenthal, Michael; Kankirawatana, Pongkiat; Charlet, Michael; A. Conry, Joan; Bensalem Owen, Meriem; S. Yerby, Mark; Herrman, Craig; Fessler, Albert; N. Modur, Pradeep; Pellon de Miranda, Fernando; King‐Stephens, David

doi:10.1212/wnl.0b013e3182635735

Public

Adjunctive perampanel for refractory partial-onset seizures

Published in Neurology • Jul 27, 2012

Authors:

Jacqueline A. French

Gregory L. Krauss

Victor Biton

Abstract

OBJECTIVE: To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment of drug-resistant partial-onset seizures. METHODS: Th...

Subject

Perampanel

Placebo

Clinical endpoint

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