High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma.

Illerhaus, Gerald; Marks, Reinhard; Ihorst, Gabriele; Guttenberger, Roland; Ostertag, Christoph; Derigs, Günther; Frickhofen, Norbert; Feuerhake, Friedrich; Volk, Benedikt; Finke, Jürgen

doi:10.1200/jco.2006.06.2117

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High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma.

Shared by NobleBlocks on Aug 20, 2006 • 12:00 AM UTC

Authors:

Gerald Illerhaus

Reinhard Marks

Gabriele Ihorst

Abstract

PURPOSE: To improve survival and reduce toxicity in primary CNS lymphoma (PCNSL) treatment, we conducted a multicenter phase II study with early high-dose chemotherapy (HDT) and autologous stem-cell transplantation (ASCT) followed by hyperfractionated whole-brain radiotherapy (WBRT) for newly diagno...

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