Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

R. Wong, Hector; Z. Cvijanovich, Natalie; Anas, Nick; L. Allen, Geoffrey; J. Thomas, Neal; T. Bigham, Michael; L. Weiss, Scott; C. Fitzgerald, Julie; A. Checchia, Paul; Meyer, Keith; P. Shanley, Thomas; W. Quasney, Michael; W. Hall, Mark; Gedeit, Rainer; J. Freishtat, Robert; Nowak, Jeffrey; S. Shekhar, Raj; J. Gertz, Shira; Dawson, Emily; Howard, Kelli; Harmon, Kelli; Beckman, Eileen; Frank, Erin; J. Lindsell, Christopher

doi:10.1164/rccm.201410-1864oc

Public

Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

Published in American Journal of Respiratory and Critical Care Medicine • Dec 9, 2014

Authors:

Hector R. Wong

Natalie Z. Cvijanovich

Nick Anas

Abstract

RATIONALE: Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling. Identifying the subclasses in real time has theranosti...

Subject

Medicine

Subclass

Septic shock

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