Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.

Bottino, Rita; A. Fernandez, Luis; Ricordi, Camillo; Lehmann, Roger; F. Tsan, M.; Oliver, Robert; Inverardi, Luca

doi:10.2337/diabetes.47.3.316

Public

Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.

Published in Diabetes • Mar 1, 1998

Authors:

Rita Bottino

Luis A. Fernandez

Camillo Ricordi

Abstract

Early impairment of islet function and graft loss limit the success of allogeneic islet transplantation. Nonspecific inflammatory events occurring at the transplant site immediately after grafting, involving the production of cytokines and free radicals and sinusoidal endothelial cell (SEC) activati...

Subject

Islet

Kupffer cell

Transplantation

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