Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Shimazu, Tadahiro; D. Hirschey, Matthew; Newman, John; He, Wenjuan; Shirakawa, Kotaro; Le Moan, Natacha; A. Grueter, Carrie; Lim, Hyungwook; R. Saunders, Laura; Stevens, Robert; B. Newgard, Christopher; V. Farese, Robert; de Cabo, Rafael; M. Ulrich, Scott; Akassoglou, Katerina; Verdin, Eric

doi:10.1126/science.1227166

Public

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Published in Science • Dec 7, 2012

Authors:

Tadahiro Shimazu

Matthew D. Hirschey

John Newman

Abstract

Concentrations of acetyl-coenzyme A and nicotinamide adenine dinucleotide (NAD(+)) affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. We report that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I hist...

Subject

Oxidative stress

Paraquat

Histone

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