Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein

C. Yeung, Kam; Janosch, Petra; W. McFerran, Brian; W. Rose, David; Mischak, Harald; M. Sedivy, John; Kölch, Walter

doi:10.1128/mcb.20.9.3079-3085.2000

Public

Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein

Published in Molecular and Cellular Biology • May 1, 2000

Authors:

Kam C. Yeung

Petra Janosch

Brian W. McFerran

Abstract

We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with MEK phosphorylation and activation by Raf-1, resulting in the suppression of both Raf-1-induced trans...

Subject

Biology

Extracellular signal-regulated kinases

Mitogen-activated protein kinase kinase

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