Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response

Hoarau, Jean‐Jacques; Jaffar Bandjee, Marie-Christine; Krejbich‐Trotot, Pascale; Das, Trina; Li-Pat-Yuen, Ghislaine; Dassa, Bérengère; Denizot, Mélanie; Guichard, Elsa; Ribéra, Anne; Henni, Tawfiq; Tallet, Frank; Pierre Moiton, Marie; Gaüzère, Bernard-Alex; Bruniquet, Sandrine; Jaffar Bandjee, Zaïnoul; Morbidelli, P.; Martigny, Gérard; Jolivet, Michel; Gay, Frédérick; Grandadam, Marc; Tolou, Hugues; Vieillard, Vincent; Debré, Patrice; Autran, Brigitte; Gasque, Philippe

doi:10.4049/jimmunol.0900255

Public

Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response

Published in The Journal of Immunology • Apr 19, 2010

Authors:

Jean‐Jacques Hoarau

Marie-Christine Jaffar Bandjee

Pascale Krejbich‐Trotot

Abstract

Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed in a prospective cohort study of 49 ho...

Subject

Immunology

Immune system

Arthritis

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