Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

JT, Bell; PC, Tsai; TP, Yang; R, Pidsley; J, Nisbet; D, Glass; M, Mangino; G, Zhai; F, Zhang; A, Valdes; SY, Shin; EL, Dempster; RM, Murray; E, Grundberg; AK, Hedman; A, Nica; KS, Small; ET, Dermitzakis; MI, McCarthy; J, Mill; TD, Spector; P, Deloukas

doi:10.1371/journal.pgen.1002629

Public

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Shared by NobleBlocks on Apr 19, 2012 • 12:00 AM UTC

Authors:

Bell JT

Tsai PC

Yang TP

Abstract

Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing and potential longevity, we tested for association ...

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