Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

Ma, Xiucui; Liu, Haiyan; R. Foyil, Sarah; J. Godar, Rebecca; J. Weinheimer, Carla; A. Hill, Joseph; Diwan, Abhinav

doi:10.1161/circulationaha.111.041814

Public

Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

Published in Circulation • May 17, 2012

Authors:

Xiucui Ma

Haiyan Liu

Sarah R. Foyil

Abstract

BACKGROUND: In myocardial ischemia, induction of autophagy via the AMP-induced protein kinase pathway is protective, whereas reperfusion stimulates autophagy with BECLIN-1 upregulation and is implicated in causing cell death. We examined flux through the macroautophagy pathway as a determinant of th...

Subject

Autophagosome

Autophagy

Programmed cell death

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