First-trimester screening for trisomies 21 and 18.

Wapner, Ronald; Thom, Elizabeth; Leigh Simpson, Joe; Pergament, Eugene; Silver, Richard; Filkins, Karen; Platt, Lawrence; Mahoney, Maurice; Johnson, Anthony; Allen Hogge, W; Douglas Wilson, R; Mohide, Patrick; Hershey, Douglas; Krantz, David; Zachary, Julia; Snijders, Rosalinde; Greene, Naomi; Sabbagha, Rudy; MacGregor, Scott; Hill, Lyndon; Gagnon, Alain; Hallahan, Terrence; Jackson, Laird; Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group, First

doi:10.1056/nejmoa025273

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First-trimester screening for trisomies 21 and 18.

Shared by NobleBlocks on Oct 9, 2003 • 12:00 AM UTC

Authors:

Ronald Wapner

Elizabeth Thom

Joe Leigh Simpson

Abstract

BACKGROUND: Screening for aneuploid pregnancies is routinely performed after 15 weeks of gestation and has a sensitivity of approximately 65 percent, with a false positive rate of 5 percent. First-trimester markers of aneuploidy have been developed, but their use in combination has not been adequate...

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