Low Muscarinic Receptor Binding in Prefrontal Cortex From Subjects With Schizophrenia: A Study of Brodmann’s Areas 8, 9, 10, and 46 and the Effects of Neuroleptic Drug Treatment

M. Crook, Jeremy; Tomaskovic‐Crook, Eva; Copolov, David; Dean, Brian

doi:10.1176/appi.ajp.158.6.918

Public

Low Muscarinic Receptor Binding in Prefrontal Cortex From Subjects With Schizophrenia: A Study of Brodmann’s Areas 8, 9, 10, and 46 and the Effects of Neuroleptic Drug Treatment

Published in American Journal of Psychiatry • Jun 1, 2001

Authors:

Jeremy M. Crook

Eva Tomaskovic‐Crook

David Copolov

Abstract

OBJECTIVE: Aberrant cholinergic inputs and synaptic neurotransmission in the prefrontal cortex induce cognitive impairment, which is a central feature of schizophrenia. Postsynaptic excitatory muscarinic cholinergic M(1) and M(4) receptors are the major cholinoceptive targets in the prefrontal corte...

Subject

Pirenzepine

Prefrontal cortex

Neuroscience

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