Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial

J. van den Bent, Martin; Carpentier, Alain; A. Brandes, Alba; Sanson, Marc; Taphoorn, Martin; J.J.A. Bernsen, Hans; Frénay, Marc; Tijssen, Cees; Grisold, Wolfgang; Sipos, Laslo; Haaxma-Reiche, Hanny; Kros, J.; C.M. Kouwenhoven, Mathilde; J. Vecht, Charles; Allgeier, Anouk; Lacombe, Denis; Gorlia, Thierry

doi:10.1200/jco.2005.04.6078

Public

Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial

Published in Journal of Clinical Oncology • Jun 16, 2006

Authors:

Martin J. van den Bent

Alain Carpentier

Alba A. Brandes

Abstract

PURPOSE: Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a multicenter randomized controlled trial, whether adjuvant procarbazine, lomustine, and vincristine (PCV) chemotherapy improves overall survival (OS) in newly diagnosed patie...

Subject

Procarbazine

Lomustine

Medicine

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