A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

Bannwarth, Sylvie; Ait-El-Mkadem, Samira; Chaussenot, Annabelle; C. Genin, Emmanuelle; Lacas‐Gervais, Sandra; Fragaki, Konstantina; Berg-Alonso, Laetitia; Kageyama, Yusuke; Serre, Valérie; Moore, David; Verschueren, Annie; Rouzier, Cécile; Le Ber, Isabelle; Augé, Gaëlle; Cochaud, Charlotte; Lespinasse, Françoise; Nguyen, Karine; de Septenville, Anne; Brice, Alexis; Yu‐Wai‐Man, Patrick; Sesaki, Hiromi; Pouget, Jean; Paquis‐Flucklinger, Véronique

doi:10.1093/brain/awu138

Public

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

Published in Brain • Jun 13, 2014

Authors:

Sylvie Bannwarth

Samira Ait-El-Mkadem

Annabelle Chaussenot

Abstract

Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are extremely rare. We report a large family with a late-onset phenotype including motor neuron disease, cognitive decline resemb...

Subject

Frontotemporal dementia

Amyotrophic lateral sclerosis

Mitochondrial respiratory chain

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