Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against <i>Mycobacterium tuberculosis</i> : Evaluation of In Vitro and Pharmacodynamic Indices That Best Predict In Vivo Efficacy

Krishan Shandil, Radha; Jayaram, Ramesh; Kaur, Parvinder; Gaonkar, Sheshagiri; L. Suresh, B.; N. Mahesh, B.; Jayashree, R.; Nandi, Vrinda; Bharath, Sowmya; Balasubramanian, V.

doi:10.1128/aac.00414-06

Public

Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis : Evaluation of In Vitro and Pharmacodynamic Indices That Best Predict In Vivo Efficacy

Published in Antimicrobial Agents and Chemotherapy • Dec 5, 2006

Authors:

Radha Krishan Shandil

Ramesh Jayaram

Parvinder Kaur

Abstract

Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we sought to determine the best in vitro and pharmacodynamic predictors of in vivo efficacy in mice. MICs for Mycobacterium tuberculosis H37Rv were 0.1 mg/liter (sparfloxacin [S...

Subject

Sparfloxacin

Ofloxacin

Moxifloxacin

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