Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation

Gesty‐Palmer, Diane; Chen, Minyong; Reiter, Éric; Ahn, Seungkirl; Nelson, Christopher; Wang, Shuntai; E. Eckhardt, Allen; L. Cowan, Conrad; F. Spurney, Robert; M. Luttrell, Louis; J. Lefkowitz, Robert

doi:10.1074/jbc.m513380200

Public

Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation

Published in Journal of Biological Chemistry • Feb 22, 2006

Authors:

Diane Gesty‐Palmer

Minyong Chen

Éric Reiter

Abstract

Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R). The purpose of the present study was to identify the contributions of distinct signaling mechanisms to PTH-stimulated activation of the mitogen-activated protein kinases (MAPK...

Subject

Parathyroid hormone

MAPK/ERK pathway

Protein kinase C

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